The single vehicle collision is thought to have happened overnight at Castlelough near Portroe but was only discovered this morning.
A local man – who was single and in his 40s – died in the crash.
It’s understood he was just a few hundred metres from his home when the incident happened.
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The road is closed as Gardaí investigate the collision.
Local diversions are in place.
This is the 8th fatality on the roads of Tipperary this year.