William Grant & Sons are winding up production of their Tullamore Dew whiskey at the C&C site on the outskirts of the town.
In 2015 the company announced they were moving operations to its distillery in County Offaly.
A number of workers have already finished up at the Annerville plant over the last year.
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The remainder will finish up today as bottling of the whiskey ends in Clonmel.
William Grant acquired Tullamore Dew along with three other spirits from drinks group C&C in 2010 for €300 million.
